KMID : 0363219930310050788
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Korean Journal of Dermatology 1993 Volume.31 No. 5 p.788 ~ p.791
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A Case of Chlorpropamide-induced Photosensitivity
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Abstract
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We report a case of a photosensitivity reaction in a 76-year-old male induced by chlorprpamide ingestion. The patient had erythematous scaly patches on the sun-exposed areas. A phtotest revealed the decreased minimal erythemal dose(MED) to
UVA(5J/cm©÷).
A photopatch test and photo-scartch test with 1% chlorpropamide ointment and 0.1% chlorpropamide solution were all negative. An oral provocation test was performed, which showed a positive result with marked decrease of MED to UVA (5J/cm©÷).
After
the
cessation of chlopropamide his skin lesions were improved markedly with complete loss of phtosensitivity. Macular hypopigmentations (leukomelanoderma) appeared on the previous erythematous patchy areas, but disappeared during the follow-up period
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